NanoVation Therapeutics Partners with Novo Nordisk on Genetic Medicines
NanoVation Therapeutics and Novo Nordisk Forge Partnership
VANCOUVER, British Columbia -- NanoVation Therapeutics, a pioneering company in the field of nucleic acid delivery, has announced a significant partnership with Novo Nordisk. This collaboration seeks to develop groundbreaking genetic medicines that focus on cardiometabolic and rare diseases. The strategic alliance merges NanoVation’s innovative long-circulating lipid nanoparticle (lcLNP™) technology with Novo Nordisk’s renowned expertise in medical research and clinical translation.
Collaboration Details and Goals
As part of the agreement, both companies will engage in collaborative efforts on two primary programs aimed at creating base-editing therapies for specific rare genetic conditions. In addition, they plan to explore up to five other potential targets in the cardiometabolic and rare disease sectors. Under this agreement, Novo Nordisk will benefit from an exclusive worldwide license for the utilization of NanoVation's LNP technology specifically for these two key programs. Moreover, NanoVation is set to receive essential research funding and has the opportunity to earn up to US$600 million through upfront cash payments, milestone achievements, and tiered royalties on any future product sales.
Leadership Perspectives on the Partnership
"We established NanoVation to assist our partners in overcoming the inherent challenges associated with conventional nucleic acid delivery systems," expressed Dominik Witzigmann, PhD, co-founder and CEO of NanoVation Therapeutics. “This collaboration with Novo Nordisk is a testament to our LNP technologies and their potential to drive the next generation of transformative genetic medicines. We are thrilled to work alongside Novo Nordisk’s accomplished team.”
Karina Thorn, PhD, Corporate Vice President and Head of Research for Global Nucleic Acid Therapies at Novo Nordisk stated, "Each genetic medication requires careful consideration of both its cargo and delivery mechanisms, necessitating dedicated innovations for both. We eagerly anticipate our partnership with NanoVation, as their distinct delivery innovations may enhance our ability to advance genetic medicine candidates with the potential for curing diseases."
Impact of NanoVation's Technology
Co-founder Pieter Cullis, PhD, recognized as a pioneer in lipid nanoparticle (LNP) technology, emphasized the importance of this partnership. "We stand at a critical juncture for genetic medicine, and this collaboration highlights NanoVation’s position as a leading innovator in nucleic acid delivery," said Cullis. "By leveraging our capabilities in delivering therapies outside the liver, combined with Novo Nordisk's specialty in cardiometabolic and rare diseases, we can potentially develop groundbreaking treatment options."
The Future of Genetic Medicine
NanoVation boasts a rapidly expanding library of novel lipids and LNP formulations. The company collaborates with industry leaders from the conceptual stage right through to lead development phases, providing tailored solutions for efficient nucleic acid delivery. Studies have preliminary indicated that NanoVation’s lcLNP technology can deliver nucleic acids to a variety of cell types beyond the liver, showcasing notable improvements in potency, safety, and stability compared to conventional delivery methods. They offer a comprehensive Intellectual Property (IP) portfolio aimed at genetic medicine development, covering aspects from lipid design to RNA modifications and LNP formulations.
About NanoVation Therapeutics
NanoVation Therapeutics is an innovator specializing in designing and developing lipid nanoparticles (LNPs) for nucleic acid delivery. The company seeks to surpass the limitations of existing nucleic acid delivery methods, particularly targeting tissues outside the liver. Its lead technology is the proprietary long-circulating LNP (lcLNP™) platform, which facilitates the functional delivery of nucleic acids to non-liver cell types. This technology has shown an improved therapeutic index in preliminary studies, and NanoVation is committed to working alongside advanced pharmaceutical and biotech firms to enable the creation of genetic medicines for previously untreatable conditions.
Frequently Asked Questions
What is the purpose of the partnership between NanoVation and Novo Nordisk?
The partnership aims to develop innovative genetic medicines targeting cardiometabolic and rare diseases using advanced LNP technology.
What technology does NanoVation Therapeutics use?
NanoVation utilizes proprietary long-circulating lipid nanoparticle (lcLNP™) technology to facilitate the delivery of nucleic acids to cells outside of the liver.
What are the financial aspects of this partnership?
NanoVation is set to receive research funding and could earn up to approximately US$600 million in upfront cash and milestone payments.
Who are the key figures in NanoVation Therapeutics?
Key figures include Dominik Witzigmann, CEO, and Pieter Cullis, co-founder and Board Chair, who are significant contributors to the field of nucleic acid delivery.
How does NanoVation's technology differ from conventional methods?
NanoVation's lcLNP technology offers enhanced potency, safety, and stability, enabling effective delivery to a broader range of cell types compared to traditional systems.
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