Molecular Instruments Enhances HCR™ Imaging Platform with New Releases

Molecular Instruments Unveils HCR™ Gold and HCR™ Pro

Molecular Instruments® (MI) has launched two exciting product lines, HCR™ Gold and HCR™ Pro, designed to greatly enhance the HCR™ imaging platform. This innovative advancement facilitates academic research and biopharma drug development by providing versatile imaging solutions for both manual and automated workflows. The newly expanded platform supports a variety of assays for simultaneous RNA and protein imaging with sample morphology maintained to the highest standards.

Introducing the HCR™ Imaging Platform

The foundational technology behind HCR™ imaging has transformed how researchers approach multiplex and quantitative RNA fluorescence in situ hybridization (RNA-FISH). This platform introduces unprecedented capabilities such as simple multiplexing and quantitative imaging, delivering the sensitivity required for challenging samples. The HCR™ platform offers unique research opportunities for imaging thick samples, including whole-mount vertebrate embryos and thick brain slices, broadening the horizons of biological research.

Advanced Fiber Using Dynamic Nanotechnology

The HCR™ imaging platform utilizes advanced dynamic nanotechnology, allowing small amplification components to penetrate biological samples seamlessly. Once inside the sample, these components trigger the growth of bright amplification polymers precisely where needed. This technology is instrumental for both the HCR™ Gold product line, focused on manual workflows, and the HCR™ Pro line, which supports automated workflows.

HCR™ Gold RNA-FISH/IF: Elevating Performance

The HCR™ Gold RNA-FISH assays have made significant improvements in enhancing signal-to-background ratios across various sample types. Notably, the 10-plex capability allows simultaneous imaging of up to 10 RNA and/or protein targets. This feature elevates the HCR™ Gold offerings, establishing a new standard for imaging delicate and whole-mount specimens that do not suit conventional imaging methods.

Streamlined Imaging with 10-Plex

With the HCR™ Gold 10-plex system, researchers can efficiently acquire images without repetitive staining and imaging cycles, significantly reducing the time and effort typically associated with traditional multiplexing techniques. This approach eliminates the cumbersome steps of repeated imaging, making it ideal for studies requiring complex data.

The HCR™ Pro RNA-CISH/RNA-FISH Workflow

The HCR™ Pro line sets a new benchmark in imaging methodology with its entirely protease-free workflows. This design maintains sample integrity while enabling high-quality RNA in situ hybridization (RNA-CISH/RNA-FISH) in tissue sections, both fixed and fresh variants, essential for biopharmaceutical development processes. Unlike conventional methods that rely on protease pretreatment, risking damage to tissue integrity, the HCR™ Pro ensures that protein targets remain intact during the imaging process.

Innovative Compatibility and Insights

Incorporating unprecedented workflow compatibility, HCR™ Pro enables simultaneous imaging of two RNA targets along with additional protein targets within a single specimen, preserving the quality necessary for both academic and clinical settings. This innovative approach not only enhances research efficiency but also optimizes the use of valuable patient samples.

The HCR™ HiFi Probe Promise

Both the HCR™ Gold and HCR™ Pro kits utilize HCR™ HiFi Probes, which provide automatic background suppression through a unique trigger mechanism, further enhancing imaging reliability. MI offers an Infinite Catalog of HCR™ HiFi Probes, adapting to any target RNA across diverse biological organisms, all without additional design costs.

About Molecular Instruments

Molecular Instruments® specializes in the development and synthesis of molecular kits, powered by the groundbreaking HCR™ imaging platform. Their technologies are vital for a range of applications spanning academic research, drug development, synthetic biology, clinical pathology, and diagnostics, positioning the company as a leader in innovative imaging solutions.

Frequently Asked Questions

What are the key benefits of the HCR™ Gold and HCR™ Pro product lines?

The HCR™ Gold enhances signal clarity and allows for imaging of multiple targets simultaneously, while the HCR™ Pro provides a protease-free workflow compatible with existing assays.

How does the HCR™ imaging platform improve RNA and protein imaging?

By utilizing dynamic nanotechnology, the HCR™ platform enables better sample penetration and promotes high signal-to-background ratios, allowing for clearer, more accurate images.

What makes the 10-plex capability unique?

The 10-plex capability allows imaging of up to 10 targets simultaneously without the need for multiple rounds of staining, saving time and resources.

What are the applications of MI's HCR™ imaging technologies?

MI's technologies are widely used in academic research, biopharma drug development, clinical pathology, and diagnostics, enhancing various scientific investigations and discoveries.

Who can benefit from the HCR™ imaging platform?

Academic researchers and biopharma developers can significantly benefit from the HCR™ imaging platform, which supports high-resolution imaging with preserved sample morphology.

About The Author

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