Moderna's Mpox Vaccine Trial Shows Promising Results Over Jynneos
Moderna Develops a Promising Mpox Vaccine
Moderna Inc. (NASDAQ: MRNA) is making strides in the development of an innovative mpox vaccine known as mRNA-1769 for adults. This vaccine is built on the company's successful mRNA technology.
Ongoing Clinical Trials
Presently, Moderna is conducting a Phase 1/2 clinical trial to assess mRNA-1769's safety, tolerability, and ability to generate an immune response in healthy participants. This substantial study involves 351 subjects and began in 2023, with results anticipated around 2025.
Results from Animal Studies
Recent findings published in a scientific paper reveal that mRNA-1769 has shown greater effectiveness than the Jynneos vaccine from Bavarian Nordic in preventing severe cases of mpox in monkeys. This new data marks a significant milestone for vaccine development against this disease.
Comparative Effectiveness of Vaccines
The study illustrates that, while the Jynneos vaccine employs the modified vaccinia Ankara (MVA), mRNA-1769 has demonstrated a remarkable capacity to reduce disease severity. In trials, monkeys vaccinated with Jynneos sustained severe lesions, classified as experiencing “grave” disease. Conversely, none of the monkeys vaccinated with mRNA-1769 reached the severe disease threshold, underscoring the promising profile of this investigational vaccine.
Benefits of mRNA-1769
Animals receiving mRNA-1769 not only experienced fewer lesions but also recovered more quickly than those immunized with the Jynneos vaccine. This highlights the potential of mRNA technologies to revolutionize vaccine efficacy against diseases like mpox.
Motivation for New Vaccine Development
Highlighting the need for improved vaccine options, the paper also points out that while Jynneos is effective, it faces challenges such as supply issues and reactogenicity concerns. The investigation into mRNA-1769 provides critical insights into developing safer and more effective vaccines for mpox.
Other Companies in the Scene
Alongside Moderna, BioNTech SE (NASDAQ: BNTX) is also at the forefront of mpox vaccine research, working on BNT166a, which is currently in a Phase 1/2 study. Early results from this trial are expected by May 2025.
Current Market Situation
As of the latest update, MRNA stock has seen a slight decline, trading down 1.39% at $72.42. Investors remain attentive to the developments surrounding this innovative vaccine and the potential market impacts.
Frequently Asked Questions
What is mRNA-1769?
mRNA-1769 is an investigational mpox vaccine developed by Moderna, using mRNA technology to trigger immune responses against mpox.
How does mRNA-1769 compare to Jynneos?
In animal studies, mRNA-1769 showed significantly better outcomes, leading to fewer lesions and lesser severity of disease compared to the Jynneos vaccine.
What clinical trials are underway for Moderna's vaccine?
A Phase 1/2 trial is currently assessing the safety and effectiveness of mRNA-1769 with results expected by 2025.
What is the significance of these findings?
The findings suggest a robust alternative to existing vaccines, potentially leading to improved protection against mpox.
What is the current status of MRNA stock?
Moderna's stock is currently down 1.39%, reflecting market reactions to the ongoing developments in their vaccine research.
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