Mid-Atlantic BioTherapeutics and Accelero Unite for Drug Discovery
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Mid-Atlantic BioTherapeutics and Accelero Biostructures Collaboration
Mid-Atlantic BioTherapeutics (MABT) and Accelero Biostructures have announced an exciting research collaboration aimed at discovering novel USP30 inhibitors that could benefit several therapeutic indications. The two companies are joining forces to tackle critical challenges in treating neurological disorders and other significant medical conditions.
Utilization of Advanced Platforms and Technologies
In their collaborative efforts, Accelero will leverage its innovative ABS-OneStep platform, which is based on high-throughput protein X-ray crystallography and advanced fragment screening techniques. This sophisticated technology serves as a powerful engine for hit generation and is enhanced with machine learning and artificial intelligence to refine the drug discovery process.
Role of Mid-Atlantic BioTherapeutics
MABT is set to play a crucial role in the subsequent stages of drug development. The team will conduct all preclinical testing and will lead the advanced development of the compounds arising from this collaboration. This integrated approach is expected to accelerate the timeline for introducing effective therapies into the market.
Significance of USP30 in Neurological Disorders
USP30, a deubiquitinating enzyme, is at the forefront of this investigation. It plays a vital role in regulating cellular processes, especially those concerning mitochondria. By modulating USP30, researchers hope to enhance the process of mitophagy, which is critical in removing damaged mitochondria. This function is essential in preserving cellular health and could play a significant role in combating oxidative stress linked to various neurological diseases.
Expert Insights on the Collaboration
David Horn, M.D., CEO of MABT, expressed enthusiasm for the collaboration, stating that targeting USP30 could lead to meaningful clinical advancements in addressing conditions such as Alzheimer's and Parkinson's diseases. The team is eager to utilize Accelero's advanced technology to rapidly identify novel compounds that can make a difference in patient outcomes.
In response, Debanu Das, Ph.D., Co-Founder and CEO of Accelero Biostructures, reiterated the potential of their ABS-OneStep platform, explaining that it has been successfully applied in various contexts and targets. They are confident it will yield new molecules specifically aimed at USP30.
About Mid-Atlantic BioTherapeutics
Founded with the mission of combating severe neurological disorders, MABT is dedicated to finding solutions for diseases such as rabies encephalitis and Alzheimer's. The company has made significant strides in this sector, having received Orphan Drug Designation for its lead programs. Their innovative approach prioritizes addressing considerable medical needs while exploring new avenues for treatment development.
About Accelero Biostructures
Accelero Biostructures has quickly established itself since its inception, drawing upon over two decades of expertise in structural genomics and protein biology. The company focuses on providing a comprehensive pipeline of solutions aimed at enabling effective structure-based drug discovery and protein engineering, with ABS-OneStep designed specifically to enhance hit generation and streamline the development of new therapeutics.
Frequently Asked Questions
What is the goal of the collaboration between MABT and Accelero?
The primary goal is to discover novel USP30 inhibitors that target neurological disorders and other medical conditions, enhancing drug development processes.
What technology does Accelero use in drug discovery?
Accelero employs its proprietary ABS-OneStep platform, which is based on high-throughput protein X-ray crystallography and enhanced by machine learning and artificial intelligence.
What role does MABT play in the collaboration?
MABT will conduct all preclinical testing and lead advanced development efforts for the compounds identified during this collaboration.
Why is USP30 an important target?
USP30 is important as it regulates mitophagy, a critical process for removing damaged mitochondria, and its modulation could greatly influence the treatment of various neurological disorders.
When was Mid-Atlantic BioTherapeutics founded?
Mid-Atlantic BioTherapeutics was founded in 2011, focusing on combating severe diseases like rabies encephalitis and Alzheimer's disease.
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