MetaVia Highlights Progress in Obesity Treatment and Finances

MetaVia Inc. Shares Significant Clinical Developments

MetaVia Inc. (NASDAQ: MTVA), a dedicated biotechnology company, is making strides in the field of cardiometabolic diseases, specifically through its promising obesity treatment, DA-1726. The company is focused on advancing its clinical trials and has dosed the first patient in an 8-week, 48 mg multiple ascending dose (MAD) cohort for its Phase 1 clinical trial. This milestone aims to explore the maximum tolerated dose and evaluate the early efficacy of DA-1726.

Collaboration and Innovation in Drug Development

To expand the potential of DA-1241, MetaVia has formed a strategic partnership with Syntekabio, leveraging artificial intelligence to explore additional indications beyond Metabolic Dysfunction-Associated Steatohepatitis (MASH). This collaboration positions MetaVia at the forefront of innovative therapeutic solutions.

Financial Outlook and Funding Adequacy

As of the end of the recent quarter, MetaVia reported a cash position of $17.6 million, which is expected to fund operations into 2026. This robust financial standing provides a solid foundation for the company to navigate its ongoing clinical trials and development objectives.

Clinical Data Highlights

Hyung Heon Kim, President and CEO of MetaVia, expressed enthusiasm regarding the company's advancements, particularly highlighting the compelling safety profile and efficacy demonstrated by the 32 mg dose of DA-1726. Initial results from previous cohorts indicated promising weight reduction trends and favorable metabolic outcomes, strengthening the rationale for the drug's development in obesity management.

Substantial Progress on DA-1241

Recent presentations have showcased significant preclinical data on DA-1241, positioning it as a first-in-class oral GPR119 agonist. This therapy is not only pivotal for MASH but also presents opportunities to address broader metabolic syndrome challenges. The dual mechanisms of action supporting liver health and glucose regulation reaffirm its potential within combination therapies.

Summary of Key Achievements

• Administration of the fifth dose for the first patient in the 8-week extended 48 mg cohort of DA-1726.
• Collaboration with Syntekabio announced to explore additional therapeutic targets.
• Successful private placement generating $10 million to support operations.
• Completion of early Phase 1 and preclinical studies indicating positive trends in efficacy and safety.

Anticipated Milestones

• Top-line data from the 8-week MAD cohort expected in the fourth quarter.
• Planning for an end-of-Phase 2 meeting with the FDA for DA-1241.

Second Quarter Financial Results Overview

For the second quarter, MetaVia reported approximately $2.3 million in research and development expenses, a notable decrease from $8.1 million in the same quarter last year, primarily due to lowered direct R&D costs associated with DA-1241 and DA-1726. General and administrative expenses remained stable at approximately $2.0 million during the quarter.

Looking Ahead

MetaVia maintains optimism about its development path, supported by strategic financial management and promising clinical results. With a strong cash buffer, the company looks ready to tackle upcoming challenges, focusing on delivering innovative therapies in obesity treatment.

Frequently Asked Questions

What is the purpose of the Phase 1 clinical trial for DA-1726?

The Phase 1 clinical trial aims to explore the maximum tolerated dose of DA-1726 for treating obesity and evaluate early efficacy and safety.

How much cash does MetaVia currently have?

MetaVia reported having $17.6 million in cash, which is expected to cover operations into 2026.

What is DA-1241 and why is it significant?

DA-1241 is a GPR119 agonist that shows promise in addressing MASH and has been indicated to improve liver health and glucose metabolism.

Who is responsible for leading MetaVia?

Hyung Heon Kim serves as the President and CEO of MetaVia, guiding the company through its clinical and strategic endeavors.

When can stakeholders expect data from the ongoing trials?

Stakeholders can anticipate top-line data from the 8-week MAD cohort of DA-1726 in the fourth quarter.

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