Medicenna Unveils Innovative Data at Leading Cancer Meeting

Medicenna's Prominent Position at the SITC Annual Meeting

Medicenna Therapeutics Corp. (TSX: MDNA, OTCQB: MDNAF), a pioneering company in clinical-stage immunotherapy, is set to make significant contributions at the esteemed annual meeting of the Society for Immunotherapy of Cancer (SITC). This event, scheduled from November 6-10 in Houston, Texas, will highlight groundbreaking clinical and preclinical data, drawing attention to the advancements in cancer treatment.

Exciting Data on MDNA11 and MDNA113

Among the key presentations will be updates on the Phase 1/2 ABILITY-1 study, which focuses on MDNA11. This investigational therapy is a long-acting, beta-enhanced 'not-alpha' interleukin-2 (IL-2) super-agonist. It aims to revolutionize treatments for patients with advanced or metastatic solid tumors, showcasing promising results from ongoing trials.

The conference will also feature innovative preclinical findings related to MDNA113, Medicenna's first-in-class, masked, tumor-targeted bifunctional anti-PD1-IL-2 Superkine. This novel compound holds special promise in treating glioblastoma, a challenging form of brain cancer, by effectively targeting tumor cells while minimizing systemic immune response.

Poster Presentations to Highlight Key Research

Medicenna has outlined a series of compelling poster presentations that will provide in-depth insights into their research. These include:

• Results from ABILITY-1 Monotherapy: This presentation will focus on the dose escalation and ongoing expansion with MDNA11 in patients with advanced solid tumors, slated for November 9.
• MDNA113's Dual Targeting Mechanism: Scheduled for November 8, it will discuss the conditionally activatable nature of MDNA113, which aims to enhance anti-tumor response while limiting systemic immune stimulation.
• IL-2 Signaling Enhancement: Also on November 8, this presentation will delve into how highly selective IL-2 receptor agonists can boost immune responses in both mouse and patient-derived glioblastomas.

Understanding the Therapeutic Potential

MDNA11's design is a result of rigorous scientific innovation. By preferentially activating immune effector cells, such as CD8+ T cells and NK cells, it overcomes the limitations of traditional treatments like aldesleukin. This cutting-edge approach aims to enhance therapeutic outcomes for patients suffering from cancer. With specific genetic modifications and a robust pharmacokinetic profile, MDNA11 is being assessed for its efficacy both as a standalone treatment and in conjunction with established therapies like pembrolizumab.

The ongoing ABILITY-1 study is pivotal, investigating the safety, tolerability, and overall effectiveness of MDNA11 in real-world settings. Its dual approach is expected to yield significant insights into combating the challenges faced in cancer immunotherapy.

Medicenna's Vision for the Future

Medicenna is not just focused on enhancing existing therapies; it is pioneering the next generation of immunotherapy. The company's innovative MDNA113 harnesses the tumor-targeted delivery system that exploits the unique characteristics of certain cancer cells. By focusing on IL-13R?2, which is frequently overexpressed in tumors, it aims to create targeted therapies that can yield better patient outcomes with fewer side effects.

This approach aligns with Medicenna's overall mission to develop transformative treatments designed specifically for solid tumors, which often evade conventional immunotherapeutic strategies. The expectations are high, with ongoing research exploring the potential of combined therapies to improve responses in solid tumors deemed 'cold'.

Frequent Engagement with the Community

As Medicenna continues to push the boundaries of cancer treatment, it remains committed to engaging with the medical community and investors. Regular updates and findings, particularly from major conferences, are integral to maintaining transparency and fostering collaboration in research.

Investors and interested parties can always access the latest information and developments through Medicenna's communication channels, ensuring they are kept informed on its progress and the broader implications of its research.

Frequently Asked Questions

What is Medicenna Therapeutics known for?

Medicenna Therapeutics is known for developing innovative immunotherapy treatments, specifically focusing on Superkines that target cancer effectively.

What are MDNA11 and MDNA113?

MDNA11 is a long-acting interleukin-2 super-agonist aimed at enhancing immune response in cancer, while MDNA113 is a bifunctional Superkine targeting tumors for better therapeutic results.

Where will the SITC Annual Meeting take place?

The SITC Annual Meeting will occur in Houston, Texas, bringing together experts from the field of immunotherapy.

When are the poster presentations scheduled?

The presentations related to MDNA11 and MDNA113 are set for November 8 and 9, providing crucial updates from the ABILITY-1 study.

How can I stay updated on Medicenna's developments?

You can stay updated by visiting Medicenna’s official website and following them on their social media platforms.

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