Marengo Therapeutics Partners with Gilead for Innovative Study

Marengo Therapeutics Partners with Gilead for Clinical Trial

Marengo Therapeutics, Inc., a pioneering clinical-stage biotech firm, has recently announced a collaboration with Gilead Sciences, Inc. This partnership aims to explore the combination of STAR0602 (Invikafusp alfa) and Trodelvy in a new clinical study tailored for metastatic breast cancer patients. The focus lies particularly on those battling triple-negative breast cancer (TNBC) and hormone receptor-positive, HER2-negative cancers.

Overview of the Clinical Collaboration

The collaborative effort intends to evaluate STAR0602, a first-in-class T cell receptor (TCR) V? selective dual T cell agonist, alongside Gilead's Trodelvy, which is a Trop-2 directed antibody-drug conjugate (ADC). This clinical investigation is set to be multi-center and will be referenced as the START-002 Phase I/II study.

Innovative Dual Action Approach

In this study, Marengo Therapeutics will oversee sponsorship while Gilead will supply Trodelvy. STAR0602 has already showcased considerable single-agent clinical activity within various PD-1 resistant tumors in the ongoing START-001 Phase 1/2 clinical trial, where it is being assessed on its own against advanced antigen-rich solid tumors.

Aiming for Better Patient Outcomes

Dr. Kevin Chin, the Chief Medical Officer at Marengo, expressed enthusiasm about the potential of merging STAR0602 with Trodelvy. He highlighted the unique characteristics of both therapeutic agents, indicating that their combined utilization could lead to more effective cancer eradication. The therapy's design intends to directly deliver cytotoxic agents to tumor sites, enhancing the immune memory formation against cancer cells.

Clinical Trial Expectations

The innovative combination trial, anticipated to launch soon, aims to thoroughly examine the safety, tolerability, and preliminary effectiveness of these two therapies working in tandem. The overarching goal is to identify possible new treatment avenues for those grappling with advanced breast cancer types.

Regulatory Status and Future Directions

It’s important to note that both STAR0602 and Trodelvy are considered investigational and have not yet received approval from health authorities globally. Consequently, the safety and efficacy concerning their combination remain unverified. However, this collaborative trial holds potential to yield vital findings that could transform treatment protocols for patients with limited options.

About Marengo Therapeutics

Marengo Therapeutics focuses on developing groundbreaking treatments using its advanced STAR platform. This approach harnesses T cell-targeting antibodies that aim to selectively influence T cell subsets crucial in combating cancer. Their dedicated team of experts in immunology and oncology is driven by the vision of enhancing patient health outcomes through innovative therapies.

Further Insights on STAR Platforms

The STAR™ Platform acts as Marengo’s proprietary technology integrating multiple unique antibody-fusion elements. It focuses on germline encoded variable (V)? regions of the TCR to stimulate T cells effectively while promoting robust anti-tumor responses.

Frequently Asked Questions

What is the purpose of the collaboration between Marengo and Gilead?

The collaboration aims to evaluate the effectiveness of STAR0602 in combination with Trodelvy for treating metastatic breast cancers, specifically TNBC and HR+/HER2- types.

What does STAR0602 aim to achieve in cancer treatment?

STAR0602 seeks to selectively enhance T cell responses to target and eliminate cancer cells, improving overall patient outcomes.

What is Trodelvy used for?

Trodelvy is an antibody-drug conjugate used primarily for treating metastatic breast cancers and is provided by Gilead for this clinical trial.

Are these treatments FDA approved?

Both therapies are currently investigational and have not received global health authority approval.

How can patients get involved in these studies?

Patients interested in the trial can contact healthcare providers for information on enrollment opportunities.

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