MannKind Highlights Innovative Inhaled Insulin Advances

Introducing Ceiling Breakers: MannKind's Innovations

MannKind Corporation (NASDAQ: MNKD) has made significant strides in the development of inhaled insulin, which is poised to transform diabetes management for both children and adults. At a recent key international conference focusing on advanced diabetes treatment technologies, the company shared compelling findings from two pivotal studies involving their flagship product, Afrezza. This inhaled form of insulin continues to capture attention and promise for those managing diabetes.

Key Findings from Recent Studies

During the 18th International Conference on Advanced Technologies and Treatments for Diabetes, MannKind presented findings from its latest clinical studies for inhaled insulin, which underscored its efficacy and safety. Dr. Kevin Kaiserman, the Senior Vice President and Therapeutic Area Head for Endocrine Diseases, expressed enthusiasm about how this data encourages ongoing discussions about the viability of Afrezza as a treatment option. He noted the increasing acceptance of inhaled insulin for adults using multiple daily injections (MDI) and automated insulin delivery (AID) systems as well.

Presentation Highlights at the Conference

MannKind’s presentations captivated attendees, showcasing several innovative aspects of inhaled insulin management for diabetes:

• What's New in Pulmonary Inhaled Insulin? Presented by Dr. Irl B. Hirsch on Thursday, March 20, during the scientific program.
• Inhaled Insulin in Pediatrics (INHALE-1 Peds Study) was presented by Dr. Michael J. Haller, examining its impacts on younger patients.
• Dr. Grazia Aleppo discussed Sustained Benefit from Use of Inhaled Insulin in the INHALE-3 Extension Study, sharing remarkable results on March 22.
• Another pivotal talk included Post-Prandial Glucose Excursion with Inhaled Insulin, which compared outcomes in youth and adults.
• The final presentation, by Dr. Anastasios Manessis, featured a Comparison of a Regimen of Inhaled Technosphere Insulin Plus Insulin Degludec Versus Usual Care in Adults.

Educational Exchange and Engagement

MannKind fostered deeper understanding by engaging attendees at their exhibit booth. The Clinical Education Team provided insights and answered inquiries, showcasing their commitment to advancing diabetes care through innovative education.

Understanding the INHALE-1 Pediatric Study

The INHALE-1 Pediatric Study represents MannKind's dedication to ensuring effective treatments for younger patients with type 1 and type 2 diabetes. This Phase 3 clinical trial aimed to determine the safety and efficacy of Afrezza when coupled with the administration of basal insulin. Involving 230 participants, the trial's primary goal was to establish non-inferiority with respect to HbA1c levels after 26 weeks of treatment.

Results from the INHALE-3 Study for Adults

For adult subjects, the INHALE-3 study delivered impressive insights into inhaled insulin treatment. Conducted over 17 weeks across 19 sites, this randomized controlled trial involved 141 participants, showcasing that patients could achieve better glycemic control by incorporating Afrezza into their usual care routines. This integration continues to reflect MannKind’s sweeping innovation agenda, significantly benefiting individuals with Type 1 diabetes.

About Afrezza and Its Impact on Diabetes Management

Afrezza is not just another insulin treatment; it represents a revolution in how diabetes management can evolve to improve daily living for patients. This rapid-acting inhaled insulin allows for better mealtime control and offers a convenient alternative to traditional injections. However, it is vital for healthcare providers and patients alike to understand its specific indications and limitations, ensuring safe and effective use.

Safety Considerations

MannKind emphasizes the importance of proper screening prior to using Afrezza, especially considering the potential risk of acute bronchospasm in patients with chronic lung diseases. Adverse reactions such as hypoglycemia and respiratory issues must also be monitored closely to ensure patient safety.

MannKind's Commitment to Innovation

At its core, MannKind Corporation is devoted to researching and developing solutions for patients suffering from serious endocrine and lung conditions. The company's focus is not only on diabetes but also on resolving unmet medical needs related to orphan lung diseases.

Please visit mannkindcorp.com to dive deeper into the range of innovative therapies and follow MannKind on social media platforms to stay updated on future developments.

Frequently Asked Questions

What is Afrezza?

Afrezza is a rapid-acting inhaled insulin designed for adults with diabetes mellitus to help manage blood sugar levels more effectively.

What did the INHALE-1 study focus on?

The INHALE-1 study focused on evaluating the efficacy and safety of inhaled insulin in children and teenagers with type 1 and type 2 diabetes.

When was the ATTD conference held?

The ATTD conference took place in March, providing a platform for cutting-edge discussions and presentations on diabetes treatments.

Who presented the findings at ATTD?

Various experts, including Dr. Kevin Kaiserman, Dr. Irl B. Hirsch, and Dr. Michael J. Haller, presented findings on inhaled insulin studies.

How does MannKind contribute to diabetes treatment?

MannKind focuses on innovative solutions to diabetes management, particularly through their development of inhaled insulin and commitment to patient education.

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