Quote:

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Bring in a PD-L1 or PD-1 downregulator (such as Leronlimab)and what you have is unprotected tumor cells being killed off by the M1 macrophages. After that 60 day window what is most likely happening is a return to a more homeostatic state."


Can I add "such as leronlimab" for purposes of clarity?

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In that 60 day window of time when leronlimab increases M1 macrophages extensively the effect is an upregulation of PD-L1/PD-1 in response. So no.