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Posted On: 06/19/2025 11:40:34 AM
Post# of 154581
Re: KenChowder #154294
Ken,
In regard to the upcoming CRC poster, you mentioned 6 CRC patients.
CytoDyn had an R&D Investor Update dated 12/7/22 which consisted of 100 slides. Slide 61 showed that there were 6 CRC patients in the CD-08 Basket Study Trial. Slide 62 (Colorectal Patients with Available PET/CT) shows CRC results.
Of the 6 patients, 1 dropped out of the study prior to a PET scan.
One was noted as “No measurable lesion on PET”.
Four were noted as “Stable Disease” or “Partial Response”.
On the left graph, three were shown as “Continued Leronlimab without further PETs”.
It is somewhat confusing to me as the graph on the left has 2 red symbols meaning “Progression with new disease”. Can progression be considered stable, depending on the degree of progression? One of those two continued Leronlimab and could have responded later.
After reviewing this slide, what are your expectations for the poster? We’ll know soon, of course, but I thought this might lead to interesting discussion in the meantime. One would think that they would not be presenting unless they have positive results like mTNBC.
https://d1io3yog0oux5.cloudfront.net/cytodyn/....22%29.pdf
In regard to the upcoming CRC poster, you mentioned 6 CRC patients.
CytoDyn had an R&D Investor Update dated 12/7/22 which consisted of 100 slides. Slide 61 showed that there were 6 CRC patients in the CD-08 Basket Study Trial. Slide 62 (Colorectal Patients with Available PET/CT) shows CRC results.
Of the 6 patients, 1 dropped out of the study prior to a PET scan.
One was noted as “No measurable lesion on PET”.
Four were noted as “Stable Disease” or “Partial Response”.
On the left graph, three were shown as “Continued Leronlimab without further PETs”.
It is somewhat confusing to me as the graph on the left has 2 red symbols meaning “Progression with new disease”. Can progression be considered stable, depending on the degree of progression? One of those two continued Leronlimab and could have responded later.
After reviewing this slide, what are your expectations for the poster? We’ll know soon, of course, but I thought this might lead to interesting discussion in the meantime. One would think that they would not be presenting unless they have positive results like mTNBC.
https://d1io3yog0oux5.cloudfront.net/cytodyn/....22%29.pdf
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