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Posted On: 05/18/2025 1:35:11 PM
Post# of 154867
Re: KenChowder #153154
That got me to thinking about Leronlimab-PLS and whether utilizing the FcRn-enhancing mutation could enhance blood brain transit as well as getting the drug accross the placenta. So I AI'ed it:
"Yes, the FcRn-enhancing mutations used in Leronlimab-PLS could potentially aid blood-brain barrier (BBB) transit. Research has shown that modifying antibody-FcRn interactions can enhance IgG transport across the BBB, improving brain penetration2.
FcRn is highly expressed at the BBB, meaning engineered antibodies can leverage receptor-mediated transcytosis to cross into the brain."
"Yes, the FcRn-enhancing mutations used in Leronlimab-PLS could potentially aid blood-brain barrier (BBB) transit. Research has shown that modifying antibody-FcRn interactions can enhance IgG transport across the BBB, improving brain penetration2.
FcRn is highly expressed at the BBB, meaning engineered antibodies can leverage receptor-mediated transcytosis to cross into the brain."
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