Stumbled on this and while dated 2009 found it of interest in that Cytodyn is hot on the trail of MASH and associated liver inflammation…key finding here was to uncover the connection between liver inflammation and brain related fatigue mediated by CCL2 and TNFa which impacted monocyte and microglia activity in the brain.This also intersects the CFS, Long COVID world at least for that one albeit very important symptom which has done much to sideline the lives of so many people. Leronlimab downregulates both CCL2 and TNFa.

https://medicalxpress.com/news/2009-02-inflam...tigue.html