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Posted On: 02/03/2025 3:09:14 AM
Post# of 154227
Quote:
Key points about GSK3915393 in Phase 1:
Target mechanism:
This drug works by targeting transglutaminase-2 (TG2).
The transglutaminase-2 enzyme that it targets needs high levels of intracellular CA-2+ to activate. Leronlimab downregulates that CA-2+.
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