Every time I see a St Jude advertisement, I wonder about CCR5 expression in children's cancer. I have tried to research it a few times. However, I have difficulty finding papers that specifically refer to children's cancer. So, I asked Google AI about it. This was the response:

"CCR5 expression is associated with the progression of several types of childhood cancer, including acute lymphoblastic leukemia (ALL), Hodgkin lymphoma, and osteosarcoma. CCR5 is a protein that can promote tumor growth and metastasis. 

Acute lymphoblastic leukemia (ALL) 

ALL cells overexpress CCR5.

ALL is the most common hematological malignancy in children.

Hodgkin lymphoma 

The CCL5/CCR5 axis is involved in the growth of classic Hodgkin lymphoma (cHL).

CCR5 and CCL5 are expressed on the surface of cHL tumor cells, monocytes, lymphocytes, and stromal cells.

Osteosarcoma 

The CCL5/CCR5 axis is commonly activated in the tumor microenvironment of osteosarcoma.

The CCL5/CCR5 axis promotes VEGF production, which accelerates angiogenesis.

CCR5 and tumor growth 

CCR5 engagement increases tumor growth by stimulating the mammalian target of rapamycin (mTOR) pathway.

CCR5 engagement also activates the Jak–STAT pathway and enhances glucose uptake.

CCR5 and other cancers 

CCR5 expression is also associated with colorectal cancer, multiple myeloma, and breast cancer.

CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling ...

In vitro, CCR5 enhances tumor growth and promotes metastasis, and its expression in CRC has been linked to shorter overall survival.6 We previously reported tha...

The Journal for ImmunoTherapy of Cancer

CCR5 and CCL5 gene expression in colorectal cancer

Jan 11, 2024 — Results. CCR5/CCL5 expression was higher in right-sided versus left-sided tumors, and positively associated with consensus molecular subtypes 1 and ...

National Institutes of Health (NIH) (.gov)

The CCL5/CCR5 Axis in Cancer Progression - PMC - PubMed Central

CCR5 engagement increases tumor growth in both autocrine and paracrine manners. Autocrine growth is characterized by the presence of functional CCR5 and the sec...

PubMed Central

Recent Advances targeting CCR5 for Cancer and its Role in Immuno ...

Jul 10, 2019 — Deregulated cellular energetics and Cancer stem cells. Tumor cells require higher rates of glucose and catabolite uptake, transfer, and utilization ...

National Institutes of Health (NIH) (.gov)

The CCL5/CCR5 Axis in Cancer Progression - MDPI

Effects of CCL5/CCR5 axis disruption in hematological malignancies. * Acute Myeloid Leukemia. The CCL5/CCR5 axis exerts profound effects on the progression of ...



MDPI

CCL5/CCR5 axis in human diseases and related treatments - PMC

Hodgkin lymphoma. Classical Hodgkin lymphoma (cHL) is a unique hematopoietic neoplasm. The character of cHL is Hodgkin and Reed-Sternberg cells (H-RS cells) inf...

National Institutes of Health (NIH) (.gov)

CCL5/CCR5 axis in human diseases and related treatments

Osteosarcoma. Osteosarcoma is a malignant childhood-bone tumor. Most of the patients with this disease are children. Derived from mesenchymal stromal cells (MSC...



ScienceDirect.com

This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental."


It seems that a CCR5 antagonist, with an impeccable safety record, would be an excellent candidate to help a lot of children. I wonder if anyone, from Cytodyn, has ever discussed cancer treatment with St Jude? It seems like Leronlimab would make an excellent treatment option to trial there.


St Jude Research Hospital Clinical Trials

https://www.stjude.org/care-treatment/clinical-trials.html