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Posted On: 10/15/2024 4:48:28 AM
Post# of 148863
Attention Ohm:
Possibly but a decrease in log of 1.77 compared to what?
I’m assuming what I’m reading tells me that PGT 121 Is a gp120 Blocker? If that’s the case, you are blocking both receptors that HIV binds to to enter a T cell. I.e., you are blocking CCR5 and gp120. I don’t think you need both unless you were involving CXCR4 (maybe not) and maybe Ohm can contribute here.
If one of those two receptors is inhibited, then the other one does not work to allow HIV into the cell. I believe this is a co-receptor scenario.
Your post stated thatPGT 121 Is located distally from the gp 120 epitope So maybe that makes it not crucial to the co-receptor with gp120 and CCR5 connection.
Regardless, if PGT 121 Is an entry inhibitor owned by ViiV It makes me very curious why they are using it with LL other than my curiosity that it is distally located from the GP 120 receptor.
Ohm, Why I have two entry inhibitors on board?
Possibly but a decrease in log of 1.77 compared to what?
I’m assuming what I’m reading tells me that PGT 121 Is a gp120 Blocker? If that’s the case, you are blocking both receptors that HIV binds to to enter a T cell. I.e., you are blocking CCR5 and gp120. I don’t think you need both unless you were involving CXCR4 (maybe not) and maybe Ohm can contribute here.
If one of those two receptors is inhibited, then the other one does not work to allow HIV into the cell. I believe this is a co-receptor scenario.
Your post stated thatPGT 121 Is located distally from the gp 120 epitope So maybe that makes it not crucial to the co-receptor with gp120 and CCR5 connection.
Regardless, if PGT 121 Is an entry inhibitor owned by ViiV It makes me very curious why they are using it with LL other than my curiosity that it is distally located from the GP 120 receptor.
Ohm, Why I have two entry inhibitors on board?
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