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Posted On: 10/15/2024 4:24:24 AM
Post# of 154130
Does this help too:
Antiviral activity
PGT121 reduced plasma HIV RNA levels by a median of 1.77 log in participants with viremia.
Mechanism of recognition
PGT121 recognizes the gp120 outer domain epitope, which is sensitive to N332.
Competition with PG9 binding
PGT121 competes more extensively with PG9 binding than the PGT128 family.
Interference with gp120 binding to CD4
PGT121 can interfere with gp120 binding to CD4, even though the PGT121 epitope is located distally from the CD4 binding site on gp120.
Antiviral activity
PGT121 reduced plasma HIV RNA levels by a median of 1.77 log in participants with viremia.
Mechanism of recognition
PGT121 recognizes the gp120 outer domain epitope, which is sensitive to N332.
Competition with PG9 binding
PGT121 competes more extensively with PG9 binding than the PGT128 family.
Interference with gp120 binding to CD4
PGT121 can interfere with gp120 binding to CD4, even though the PGT121 epitope is located distally from the CD4 binding site on gp120.
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