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OK,... so given the fact that it is already recognized as "Severe"...at what point is the Tipoff...for Leronlimab to be used effectively.

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The earlier the better of course. In trials and compassionate use we've often been relegated to last chance status when so much damage has been done that prolongation of life by a fairly short period is the only possibility. The best use for leronlimab is first line treatment or a preventative.