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I found this Nature article very useful and you will begin to understand how central NF-κB is to the inflammatory process. Take time to absorb figure 1, which shows the relationship to chemokines.

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But that's only the direct level of action. Then you have to follow what the actions on those chemokines do to other chemokines and how the actions of those chemokines affect other chemokines and so on and so forth. It's a complete nightmare to analyze.