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Posted On: 05/28/2024 7:56:03 PM
Post# of 155026
You may also like to noodle on reactive astrocytes. Re: Alzsheimers Disease. Similarly to M1 v M2 Macrophages, reactive atrocytes also change phenotypes, when conditions change.
From dwfls original link Re: Plexin-B1,
“The study, which focuses on the role of reactive astrocytes and the plexin-B1 protein in Alzheimer’s pathophysiology, provides crucial insights into brain cell communication and opens the door to innovative treatment strategies.”
What are reactive astrocytes?
“Reactive astrocytes are astrocytes that undergo morphological, molecular, and functional changes in response to pathological situations in surrounding tissue (that is, due to CNS disease, injury, deleterious experimental manipulation)”
https://www.nature.com/articles/s41593-020-00783-4
“We found that embryonic astrocytes and microglial cells express CCR5, CCR3, and CXCR4 transcripts. Intracellular calcium levels in astrocytes were found to increase following application of RANTES, MIP-1beta (CCR5-agonist), SDF-1alpha (CXCR4-agonist), but not eotaxin (CCR3-agonist).”
“When stimulated by disease or injury, astrocytes become activated and undergo a series of changes, including alterations in gene expression, hypertrophy, the loss of inherent functions, and the acquisition of new ones. Studies have shown that astrocytes are highly heterogeneous with respect to their gene expression profiles, and this heterogeneity accounts for their observed context-dependent phenotypic diversity. In the inured CNS, activated astrocytes play a dual role both as regulators of neuroinflammation and in scar formation”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733560/
“Based on the lessons from
unsuccessful neuron-focused research for an AD cure, non-cell autonomous mechanisms including brain
inflammation and reactive astrocytes have recently been in the spotlight as potential therapeutic targets
for AD. Studies have shown that reactive astrocytes are not only the result of inflammatory defense
reactions, but also an active catabolic decomposer that acts by taking up amyloid beta toxins. Here, we
give an overview of the characteristics of reactive astrocytes as pathological features of AD.”
https://www.researchgate.net/profile/C-Justin...-sword.pdf
Good day today. Hoping for good news on Thursday!!
From dwfls original link Re: Plexin-B1,
“The study, which focuses on the role of reactive astrocytes and the plexin-B1 protein in Alzheimer’s pathophysiology, provides crucial insights into brain cell communication and opens the door to innovative treatment strategies.”
What are reactive astrocytes?
“Reactive astrocytes are astrocytes that undergo morphological, molecular, and functional changes in response to pathological situations in surrounding tissue (that is, due to CNS disease, injury, deleterious experimental manipulation)”
https://www.nature.com/articles/s41593-020-00783-4
“We found that embryonic astrocytes and microglial cells express CCR5, CCR3, and CXCR4 transcripts. Intracellular calcium levels in astrocytes were found to increase following application of RANTES, MIP-1beta (CCR5-agonist), SDF-1alpha (CXCR4-agonist), but not eotaxin (CCR3-agonist).”
“When stimulated by disease or injury, astrocytes become activated and undergo a series of changes, including alterations in gene expression, hypertrophy, the loss of inherent functions, and the acquisition of new ones. Studies have shown that astrocytes are highly heterogeneous with respect to their gene expression profiles, and this heterogeneity accounts for their observed context-dependent phenotypic diversity. In the inured CNS, activated astrocytes play a dual role both as regulators of neuroinflammation and in scar formation”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733560/
“Based on the lessons from
unsuccessful neuron-focused research for an AD cure, non-cell autonomous mechanisms including brain
inflammation and reactive astrocytes have recently been in the spotlight as potential therapeutic targets
for AD. Studies have shown that reactive astrocytes are not only the result of inflammatory defense
reactions, but also an active catabolic decomposer that acts by taking up amyloid beta toxins. Here, we
give an overview of the characteristics of reactive astrocytes as pathological features of AD.”
https://www.researchgate.net/profile/C-Justin...-sword.pdf
Good day today. Hoping for good news on Thursday!!
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