Thanks for the hyperlink and your comment. The CCL5/CCR5 axis appears to definitely impact PCNA. I read many years ago the atherosclerotic process is not as simple as “hey I’m a lipid traveling in the vascular compartment in high concentration, where can I adhere.” It is actually triggered by a process which causes smooth muscle cells to migrate to the intima, in turn disrupting the dynamics of fluid flow with a consequent propensity toward lipid deposition downstream of the vascular irregularity. CCL5 is definitely a trigger in this process; I was not aware RANTES is also activated in endothelial cells.

It is astounding the ripple-effects from CCR5, the ultimate pin-ball wizard bouncing off and fist-bumping so many disease states, which practically beg to be reigned in. Cytodyn should have you on retainer to peel back the many layers of the multifaceted Leronlimab.