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Posted On: 08/03/2023 8:57:43 AM
Post# of 154874
It's possible that p27 (upregulated due to CCL5 (RANTES) downregulation) affects PCNA through knockdown of CDK2, CDK4 and CDK6 (on the regulator list). It's also possible that p21, p38 or p57 that also downregulate PCNA are the factors. p21, p38 and p57 are on my list of proteins to look at to see if they are effected by leronlimab.
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look at p21, p38, p57, tim3, il-5, TGF-β1,p53 cancer good, mdm2 cancer bad, IFNβ, ATP (via CCL5)
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Similarly, CCR5 knockdown resulted in a significant decrease in the CCL5-induced protein expression of CDK2, CDK4, cyclin D1, cyclin E, pRB, and PCNA, while increasing the p27kip1 level
https://karger.com/cpb/article/47/2/707/73640...oth-Muscle
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