>Excerpt: To date, 50 chemokines have been identified [Citation9]. Although their main role is recruitment and activation of the immune response, their important role in the process of tumor cell invasion, metastasis and immune response escape has been increasingly recognized [Citation10]. Most tumors promote their own growth by recruiting stromal cells to shape the local chemokine network [Citation11]. Among the known human chemokines, CCL4, CCL5, CXCL9 and CXCL10 are closely related to CD8+ T-cell infiltration [Citation12]. Among these proteins, CCL5 affects tumor progression in an autocrine or a paracrine manner, such as by directly affecting cancer cell proliferation, migration and survival through its autocrine function or by indirectly recruiting inflammatory cells into the tumor microenvironment (TME)through paracrine function, thus shaping the TME for its own survival [Citation13]. In this study, we explored the role played by the chemokine CCL5in the occurrence and development of CRC.."

https://www.tandfonline.com/doi/full/10.1080/...23.2205168