Yes I think they have already had such success in animal model using leronlimab. I don't understand why they would want to do LRM gene therapy with AAV, other than it is novel and would possibly provide more continuous coverage of LRM. However, Tcells don't last that long, so the I don't think TCell AAV would produce LRM for very long. I wonder how long would one need to block CCR5 after TCell adoptive cell transfer / therapy?

Will have to look for the monkey HIV cure work by Sacha later on when time permits.