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Would you tend to think that with the 350mg LL dosing, 100% RO was achieved or do you think that had 700mg been dosed in those same patients, LL would have achieved the same, better or worse outcomes than it achieved dosed at 350mg?

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I do not think 350mg would achieve 100% RO. 525mg night come close enough that any gains from 700mg would be negligible.