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Posted On: 06/10/2022 8:45:48 AM
Post# of 154867
Re: chazzledazzle #124486
Excellent thought chazzledazzle.
Yes, I would think that the older scar tissue is considerably more dense then the newer scar tissue albeit, less dense, akin to what I just replied just now.
I was suggesting the density of the tissue as possibly a reason why the 700 mg did not work as well because the 700 being 100% receptor occupancy would potentially add to the density thereby pressing other receptors of other cytokines which would need to be activated in order to remove the scar tissue. However, because of the density of the tissue those activators and those cytokines were not being triggered and therefore did not remove scar tissue. Somehow it’s possible that the density of the tissue correlates to how well Leronlimab works or why the 350 mg works better than the 700 as the 700 is 100% receptor occupancy whereas the 350 is less than that. 700 mg LL might be adding to the congestion within that high density fibrotic tissue.
And the congestion itself may be adding to the inflammation which may be increasing the CT1 msec measurement.
Yes, I would think that the older scar tissue is considerably more dense then the newer scar tissue albeit, less dense, akin to what I just replied just now.
I was suggesting the density of the tissue as possibly a reason why the 700 mg did not work as well because the 700 being 100% receptor occupancy would potentially add to the density thereby pressing other receptors of other cytokines which would need to be activated in order to remove the scar tissue. However, because of the density of the tissue those activators and those cytokines were not being triggered and therefore did not remove scar tissue. Somehow it’s possible that the density of the tissue correlates to how well Leronlimab works or why the 350 mg works better than the 700 as the 700 is 100% receptor occupancy whereas the 350 is less than that. 700 mg LL might be adding to the congestion within that high density fibrotic tissue.
And the congestion itself may be adding to the inflammation which may be increasing the CT1 msec measurement.
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