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Posted On: 05/28/2022 1:14:25 PM
Post# of 148889
"Yes, the affinity that LL has with CCR5 exceeds that even of CCL5 or HIV with CCR5. Once LL binds to CCR5, there is no separating the two.
No separation, not even after the BBB as someone somewhere suggested."
This is an important point, especially if combined with the fact that Cytodyn's claims regarding RO in brain cells are based upon CD4+ T-cells.
Because it means that 1) leronlimab is entering the brain exclusively through a piggy-back transport on white blood cells, and 2) leronlimab cannot affect any cells other than the cells upon which leronlimab piggy-backed into the brain.
Which might be just fine. It might be plenty good enough to get the leronlimab-bound cells, whether T-cells or macrophages, into the brain to do their work while bound with leronlimab.
No separation, not even after the BBB as someone somewhere suggested."
This is an important point, especially if combined with the fact that Cytodyn's claims regarding RO in brain cells are based upon CD4+ T-cells.
Because it means that 1) leronlimab is entering the brain exclusively through a piggy-back transport on white blood cells, and 2) leronlimab cannot affect any cells other than the cells upon which leronlimab piggy-backed into the brain.
Which might be just fine. It might be plenty good enough to get the leronlimab-bound cells, whether T-cells or macrophages, into the brain to do their work while bound with leronlimab.
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