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Posted On: 05/26/2022 6:48:37 AM
Post# of 154147
I see your point.
When it comes to scarring and fibrosis, I would tend to think the blood supply to those tissues is minimal if not non-existent. Therefore, any increase at least by diffusion to the surrounding encapsulating wall by sheer volume might show promise.
Secondly, in the NASH conference where Mazen Noureddin, MD, Cedars-Sinai Medical Center, they were discussing the non linear benefits of weight loss.
One statement made:
So what this is suggesting is that just modest changes in weight loss, going from 5% to 7% has changes which may correlate going from a NAS of 3 to a NAS of 1 for 5% weight loss; and going from a NAS of 4 or 5 to a NAS of 1 or 2 for 7% weight loss. Lastly, fibrosis is associated with a NAS of 8 a patient would only need to lose 10% weight to begin losing fibrous tissue. NAS 8 >> NAS 5 with 10% weight loss.
That's why I am so bullish on doubling LL from 350 to 700mg. I think those cells which produce the fibrous scar tissue may be harder to access than the hepatocytes which produce fat.
When it comes to scarring and fibrosis, I would tend to think the blood supply to those tissues is minimal if not non-existent. Therefore, any increase at least by diffusion to the surrounding encapsulating wall by sheer volume might show promise.
Secondly, in the NASH conference where Mazen Noureddin, MD, Cedars-Sinai Medical Center, they were discussing the non linear benefits of weight loss.
One statement made:
Quote:
"Modest 5% weight loss is associated with both cardiometabolic benefit and reversal of steatosis."
"Greater weight loss often associated with reversal of steatohepatitis (usually with weight loss >7% or fibrosis (usually with weight loss of > 10%).
So what this is suggesting is that just modest changes in weight loss, going from 5% to 7% has changes which may correlate going from a NAS of 3 to a NAS of 1 for 5% weight loss; and going from a NAS of 4 or 5 to a NAS of 1 or 2 for 7% weight loss. Lastly, fibrosis is associated with a NAS of 8 a patient would only need to lose 10% weight to begin losing fibrous tissue. NAS 8 >> NAS 5 with 10% weight loss.
That's why I am so bullish on doubling LL from 350 to 700mg. I think those cells which produce the fibrous scar tissue may be harder to access than the hepatocytes which produce fat.
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