just thinking out loud. if you have a filter, the BBB and it has certain size holes to only permit things small through, but then it becomes inflamed as a result of some inflammatory process, say the development of scar tissue or amyloid plaques or fibrotic overlay, then the holes would tend to get clogged even further and instead of getting bigger from swelling, their walls would grow closer together like a nose full of mucous not permitting any air through.

Quote:

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Our recent data that leronlimab crosses the blood-brain barrier with 70-75% receptor occupancy of the CCR5 receptors in the brain (Macaque model) is encouraging for the potential to enhance recovery in stroke and traumatic brain injury and explore a variety of central nervous system pathology.”

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https://www.globenewswire.com/news-release/20....%E2%80%9D