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amyloid load does not correlate with cognition.

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Which is why approval of Aduhelm was such a farce. No scientific evidence that it would benefit patients and brain bleed on top of it.

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It is small enough to cross to bind to the Microglial cells in the Brain.

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It's not that leronlimab is small enough. Back in 2019 I said that leronlimab would cross because the inflammatory state increases leakage in the blood brain barrier allowing larger molecules to cross. That inflammation causes the microglial activation. As the inflammation and microglial activation subside the leakage would decrease to the point it would not cross. Which is a good thing.

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