Many thanks Ohm. That is now included.

___________________________

Posted On: 02/25/2022 6:03:25 PM
Posted By: ohm20
Re: CGC #119214
My little shorthand of leronlimab's action may help.

Leronlimab inhibits angiogenesis by downregulating VEGF, anti-trafficking of tumor cells, increase in tumor fighting NKT cells, debases DNA repair, stops the recruitment of Tregs to tumor sites (Tregs promote tumor immunity), downregulates IL-13 a tumor protectant and IL-4 (IL-4 promotes tumor immunity), upregulates IFN-gamma promoting tumor cell death and downregulates PD-L1. Downregulates CDK2/4/6, cyclin D1, cyclin E, and PCNA which are implicated in tumor cell growth. Upregulates p27 and p53 which are both tumor suppressors.