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Posted On: 02/25/2022 6:03:25 PM
Post# of 148899
My little shorthand of leronlimab's action may help.
Leronlimab inhibits angiogenesis by downregulating VEGF, anti-trafficking of tumor cells, increase in tumor fighting NKT cells, debases DNA repair, stops the recruitment of Tregs to tumor sites (Tregs promote tumor immunity), downregulates IL-13 a tumor protectant and IL-4 (IL-4 promotes tumor immunity), upregulates IFN-gamma promoting tumor cell death and downregulates PD-L1. Downregulates CDK2/4/6, cyclin D1, cyclin E, and PCNA which are implicated in tumor cell growth. Upregulates p27 and p53 which are both tumor suppressors.
Leronlimab inhibits angiogenesis by downregulating VEGF, anti-trafficking of tumor cells, increase in tumor fighting NKT cells, debases DNA repair, stops the recruitment of Tregs to tumor sites (Tregs promote tumor immunity), downregulates IL-13 a tumor protectant and IL-4 (IL-4 promotes tumor immunity), upregulates IFN-gamma promoting tumor cell death and downregulates PD-L1. Downregulates CDK2/4/6, cyclin D1, cyclin E, and PCNA which are implicated in tumor cell growth. Upregulates p27 and p53 which are both tumor suppressors.
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