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Posted On: 11/08/2021 9:01:39 AM
Post# of 148903
Jlang,
No one is claiming that leronlimab addresses the underlying ultimate pathology.
While not addressing the myriad of underlying pathologies (SOD1/FUS/TDP43 proteins, mitochondrial dysfunction, calcium transport pathologies), leronlimab may very well reduce the microglial and macrophage mediated secondary inflammation.
However, there are multiple steps in the pathology of most diseases.
Understanding the pathology of diseases is important. Ignoring the intermediate and drugable steps of disease progression misses important opportunities to ameliorate disease, even if not curative.
No one is claiming that leronlimab addresses the underlying ultimate pathology.
While not addressing the myriad of underlying pathologies (SOD1/FUS/TDP43 proteins, mitochondrial dysfunction, calcium transport pathologies), leronlimab may very well reduce the microglial and macrophage mediated secondary inflammation.
However, there are multiple steps in the pathology of most diseases.
Understanding the pathology of diseases is important. Ignoring the intermediate and drugable steps of disease progression misses important opportunities to ameliorate disease, even if not curative.
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