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Posted On: 11/08/2021 6:38:35 AM
Post# of 72440
Friends in IPIX!
Having retired from MRK in 2007 and worked for Bayer 25 years and BMY 5 years competing against PFE, a Co I actually had a personal vendetta against over a Hiring decision in the late 70s... I have some perspective on the new Oral retro virals from PFE and MRK Id like to share.
Ok we know about dosing and side effects..thats not new but heres a REAL WORLD perspective given the current Epidemic and how one goes about a Dx and Tx!
The Dx would be for insureds by a PC referral..this takes a day or so to get..NO DOC will see you in the office until this is done w/ RESULTS ..keep in mind a Time clock effect and Covid specifically VIRAL REPLICATION!It must be caught early and treated early!
Than U get a Robo visit or in person appt...that would take some time maybe a week to get in....these drugs are designed to act on ACTIVE REPLICATING VIRUS...they are worthless after 7 days, since most of the viral damage is done early on Days 1-3 w/ symptoms w/ active replication..to KILL they virus they must be given Early!.
Given this FACT of how they work and their MOAs..I dont think in practicality they will sell as well, and even if they do...they will have little effect after 7 days of Symptoms..its get Tx EARLY ON like a stat order or FAIL imo....many break throughs of refractory Covid Infection will therefore be admitted!
Given this scenario, I am much Happier w/ a Tx like BRIL which will be effective in serious cases...I think BRILS main activity will be its effect on COMPLIMENT CASCADE and Binding site interference against ACE2....end organ damage will be the MAIN issue...slowing the CC and inflammation will be key to survival...
This will be a more Finite and Controlled pop to Tx with much better chance to show actual clinical relevance imo..
Finally once admitted to any Hospital and given O2 support, given Immuno compromise, ones Endogenous Bacterial Profile changes in 48 hrs to HOSPITAL DRIVEN BUGS...this is a fact of Life and why MDR antibiotics are so HOT and Valuable...this will become the MAIN issue along w/ CC that Docs will attack..so Pneumonia is short and Hosptal Acquired Pneumonia specifically will emerge quickly!
I like the fact that BRIL is very BACTI Gm+/- active and already proven a P2-2 trial skin structure infection superior to Daptomycin! So in short I like BRIL as an ANTI INFECTIVE against common hospital bugs like STAPH and ENTEROCCOCUS...If our data is good this might become a provable issue ina P-3..it certainly will be looked at!
Just need to contain ourselves a bit longer to see where this is all going!
RP
Having retired from MRK in 2007 and worked for Bayer 25 years and BMY 5 years competing against PFE, a Co I actually had a personal vendetta against over a Hiring decision in the late 70s... I have some perspective on the new Oral retro virals from PFE and MRK Id like to share.
Ok we know about dosing and side effects..thats not new but heres a REAL WORLD perspective given the current Epidemic and how one goes about a Dx and Tx!
The Dx would be for insureds by a PC referral..this takes a day or so to get..NO DOC will see you in the office until this is done w/ RESULTS ..keep in mind a Time clock effect and Covid specifically VIRAL REPLICATION!It must be caught early and treated early!
Than U get a Robo visit or in person appt...that would take some time maybe a week to get in....these drugs are designed to act on ACTIVE REPLICATING VIRUS...they are worthless after 7 days, since most of the viral damage is done early on Days 1-3 w/ symptoms w/ active replication..to KILL they virus they must be given Early!.
Given this FACT of how they work and their MOAs..I dont think in practicality they will sell as well, and even if they do...they will have little effect after 7 days of Symptoms..its get Tx EARLY ON like a stat order or FAIL imo....many break throughs of refractory Covid Infection will therefore be admitted!
Given this scenario, I am much Happier w/ a Tx like BRIL which will be effective in serious cases...I think BRILS main activity will be its effect on COMPLIMENT CASCADE and Binding site interference against ACE2....end organ damage will be the MAIN issue...slowing the CC and inflammation will be key to survival...
This will be a more Finite and Controlled pop to Tx with much better chance to show actual clinical relevance imo..
Finally once admitted to any Hospital and given O2 support, given Immuno compromise, ones Endogenous Bacterial Profile changes in 48 hrs to HOSPITAL DRIVEN BUGS...this is a fact of Life and why MDR antibiotics are so HOT and Valuable...this will become the MAIN issue along w/ CC that Docs will attack..so Pneumonia is short and Hosptal Acquired Pneumonia specifically will emerge quickly!
I like the fact that BRIL is very BACTI Gm+/- active and already proven a P2-2 trial skin structure infection superior to Daptomycin! So in short I like BRIL as an ANTI INFECTIVE against common hospital bugs like STAPH and ENTEROCCOCUS...If our data is good this might become a provable issue ina P-3..it certainly will be looked at!
Just need to contain ourselves a bit longer to see where this is all going!
RP
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