I have no way of knowing any worthwhile answers to your questions.   I cited TOB's post of a few days prior, just a detail from a poster or other source from Cellceutix that mentioned Kevetrin posing a low risk of accumulation, "undetectable concentrations w/in 24 hours"....All depends on dosage. Blood levels of a drug are just how much are in the body, ie. take ibuprofen every four hours, your blood levels of ibuprofen will increase, your liver enzymes would eventually rise if taken to excess. So far Kevetrin appears well received at current dosages, but whether it will be effective we will all know sooner or later