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Posted On: 09/17/2021 6:44:21 PM
Post# of 148878
Re: Buddyboy20 #104389
CRISPR and Sangamo’s ZFN both have a good chance of a cure in my opinion.
These methods of Gene DNA modification basically cut out HIV sequence from the DNA string and repair the broken strands of DNA to be like uninfected T-cells.
ZFN is more accurate than CRISPR but I believe it’s more costly.
I just can’t understand why Cytodyn are chasing an HIV cure when Leronlimab only attaches itself to the CCR receptor. The only thing I can think of is to provide a patient with Leronlimab and insert uninfected T-cells from a donor in such a quantity so they attack the infected cells. The cells would either have to be from a compatible donor or they are relying on GVHD properties of Leronlimab to stop rejection. But then the patient still has a reservoir of latent cells which can re-awake at anytime. The so called ‘Kick and Kill’ method (if it works at all) which is a combination of drugs which awakes latent HIV cells and the other drug kills the infected cells and free floating HIV wouldn’t require Leronlimab either.
Maybe I’m missing something here!
These methods of Gene DNA modification basically cut out HIV sequence from the DNA string and repair the broken strands of DNA to be like uninfected T-cells.
ZFN is more accurate than CRISPR but I believe it’s more costly.
I just can’t understand why Cytodyn are chasing an HIV cure when Leronlimab only attaches itself to the CCR receptor. The only thing I can think of is to provide a patient with Leronlimab and insert uninfected T-cells from a donor in such a quantity so they attack the infected cells. The cells would either have to be from a compatible donor or they are relying on GVHD properties of Leronlimab to stop rejection. But then the patient still has a reservoir of latent cells which can re-awake at anytime. The so called ‘Kick and Kill’ method (if it works at all) which is a combination of drugs which awakes latent HIV cells and the other drug kills the infected cells and free floating HIV wouldn’t require Leronlimab either.
Maybe I’m missing something here!
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