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Analysis of samples from the patient showed that the virus evolved rapidly after the plasma therapy, developing mutations that changed how it could infect cells and resist antibodies. The conditions turned out to be ripe for viral evolution. “This is a blueprint for how variants emerge,” Gupta says.

The plasma treatments did not rid the man of the virus, and in fact had little impact on the amount of virus detected. But the plasma had a remarkable effect on the genetic makeup of the viral population that the patient harbored. Seemingly in response to the antibodies contained within the plasma, the virus produced “escape mutations,” changes in the genetic code that helped it to evade detection by the sticky antibodies.
https://www.scientificamerican.com/article/co...e-systems/

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