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Posted On: 04/21/2021 9:22:21 PM
Post# of 154989
Re: MD VIROLOGIST #87405
Now here is an Pourhassan statement that needs the secret decoder.
What in the heck is he talking about?
"Tropism" is how you say "There is more than one kind of HIV virus."
There are many types of HIV viruses that are different from each other because their molecules are different.
My understainding is that there is one and only HIV virus that uses CCR5 to infect cells. I think its called either R4 or R5.
It is my further understanding that leronlimab does one and only one thing to prevent HIV: Leronlimab binds CCR5 so that the one and only one HIV virus flavor R4-or-R5 cannot get into the cell.
How is it conceivable that a receptor occupancy test can discriminate leronlimab responders independent of the special kind of virus that they are suffering from?
First of all, when you measure CCR5 receptor occupancy all of the CCR5s are unoccupied. Thats what they do. They sit around waiting for something to show up. So how in the world would CCR5 receptor occupancy be an indicator of leronlimab treatability?
And then there is the whole thing that all the other types of HIV viruses do not occupy CCR5. How does a CCR5 receptor occupancy test tell anything about those people?
Does anyone have the secret Pourhassan decoder?
What in the heck is he talking about?
"Tropism" is how you say "There is more than one kind of HIV virus."
There are many types of HIV viruses that are different from each other because their molecules are different.
My understainding is that there is one and only HIV virus that uses CCR5 to infect cells. I think its called either R4 or R5.
It is my further understanding that leronlimab does one and only one thing to prevent HIV: Leronlimab binds CCR5 so that the one and only one HIV virus flavor R4-or-R5 cannot get into the cell.
How is it conceivable that a receptor occupancy test can discriminate leronlimab responders independent of the special kind of virus that they are suffering from?
First of all, when you measure CCR5 receptor occupancy all of the CCR5s are unoccupied. Thats what they do. They sit around waiting for something to show up. So how in the world would CCR5 receptor occupancy be an indicator of leronlimab treatability?
And then there is the whole thing that all the other types of HIV viruses do not occupy CCR5. How does a CCR5 receptor occupancy test tell anything about those people?
Does anyone have the secret Pourhassan decoder?
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