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Posted On: 02/04/2021 9:54:08 PM
Post# of 149009
Re: chazzledazzle #76337
Quote:
Does the halting angiogenesis require the CCR5/CCL5 axis or pathway?
Angiogenesis will still occur absent CCR5 or CCL5. As CCR5/CCL5 levels increase so do levels of VEGF through the mTORc pathway. High
VEGF induces increased angiogenesis. Leronlimab disrupts mTORc downregulating VEGF.
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