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Posted On: 11/22/2020 10:25:03 PM
Post# of 148936
I finally understand my own question. The graphic you have shown does not show an intervention by something like LL. But only the progression of tumor growth through the CCL5/CCR5 Axis.
Seems so obvious now. Sheesh. I shoulda just read the flipping paper. It woulda saved my whole evening....
Yet again, thank you CTMedic,
“2. Involvement of the CCL5/CCR5 Axis in Cancer Progression
The CCL5/CCR5 axis facilitates tumor progression through multiple mechanisms (Figure 1). It increases tumor growth (1), induces extracellular matrix remodeling (2), enhances tumor cell migration (metastasis formation) (3), supports cancer stem cell expansion (4), enables cancer cell resistance to drugs (5,6), decreases the cytotoxicity of DNA-damaging agents (5), deregulates cellular energetics (metabolic reprogramming) (7), promotes angiogenesis (
, recruits immune and stromal cells (9), and induces the immunosuppressive polarization of macrophages “
Seems so obvious now. Sheesh. I shoulda just read the flipping paper. It woulda saved my whole evening....
Yet again, thank you CTMedic,
“2. Involvement of the CCL5/CCR5 Axis in Cancer Progression
The CCL5/CCR5 axis facilitates tumor progression through multiple mechanisms (Figure 1). It increases tumor growth (1), induces extracellular matrix remodeling (2), enhances tumor cell migration (metastasis formation) (3), supports cancer stem cell expansion (4), enables cancer cell resistance to drugs (5,6), decreases the cytotoxicity of DNA-damaging agents (5), deregulates cellular energetics (metabolic reprogramming) (7), promotes angiogenesis (
, recruits immune and stromal cells (9), and induces the immunosuppressive polarization of macrophages “
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