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Posted On: 11/22/2020 5:25:49 PM
Post# of 148984
Re: chazzledazzle #66190
Chazzledazzle,
I'm learning as I go, but I'll try.
Step 5. CCL5 upregulates DNA repair mechanisms and PD-1, which when expressed on cell surfaces, blocks cell death from cytotoxic T cells.
Step 6. CCL5 driven recruitment of CAF(Cancer associated fibroblasts), MSC (mesenchymal stem cells) and T cells, helps created a microenvironment/wall of defense such that the cytoxic drugs never reach the targeted cancer cells.
I'm sure someone can correct/clarify this basic explanation.
I'm learning as I go, but I'll try.
Step 5. CCL5 upregulates DNA repair mechanisms and PD-1, which when expressed on cell surfaces, blocks cell death from cytotoxic T cells.
Step 6. CCL5 driven recruitment of CAF(Cancer associated fibroblasts), MSC (mesenchymal stem cells) and T cells, helps created a microenvironment/wall of defense such that the cytoxic drugs never reach the targeted cancer cells.
I'm sure someone can correct/clarify this basic explanation.
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