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Posted On: 09/29/2020 9:32:38 AM
Post# of 148899
The lancet article also supports thrombosis as a direct response to immune over reaction (echoed by Dr. Patterson’s observation that leronlimab patients did not develop blood clots).
“ In SARS-CoV-2, NET [ neutrophil extracellular traps] formation has been postulated as a predisposing factor to thrombi formation.38 We validated this hypothesis by showing marked DNA traps and early NET formation (swollen citH3-positive nuclei) in several organs. The frequently observed NETs and NET–platelet aggregates suggest a contribution to the poorly understood coagulopathy in COVID-19.”
And
“ The disproportionate presence of aggregated neutrophils and NETs in comparison with the sporadic presence of virus suggests an autonomous maladaptive immune response. This study underlines the importance of targeting the immune response in patients with COVID-19 and substantiates the possible beneficial effects of low-dose dexamethasone in the treatment of COVID-19.39 The implied role of NETs in persistent immune activation and in SARS-CoV-2-induced coagulopathy has created novel questions in the understanding of COVID-19.”
The demonstration of immune dysregulation in severe Covid sets a grand stage for Dr. Patterson’s leronlimab CCR5/RANTES article and CD12.
Very hard to be patient.
“ In SARS-CoV-2, NET [ neutrophil extracellular traps] formation has been postulated as a predisposing factor to thrombi formation.38 We validated this hypothesis by showing marked DNA traps and early NET formation (swollen citH3-positive nuclei) in several organs. The frequently observed NETs and NET–platelet aggregates suggest a contribution to the poorly understood coagulopathy in COVID-19.”
And
“ The disproportionate presence of aggregated neutrophils and NETs in comparison with the sporadic presence of virus suggests an autonomous maladaptive immune response. This study underlines the importance of targeting the immune response in patients with COVID-19 and substantiates the possible beneficial effects of low-dose dexamethasone in the treatment of COVID-19.39 The implied role of NETs in persistent immune activation and in SARS-CoV-2-induced coagulopathy has created novel questions in the understanding of COVID-19.”
The demonstration of immune dysregulation in severe Covid sets a grand stage for Dr. Patterson’s leronlimab CCR5/RANTES article and CD12.
Very hard to be patient.
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