There are a few ways leronlimab can cross. Inflammatory conditions cause a leaky blood brain barrier allowing large molecules to get through. Attachment to the CCR5 receptor. While trying to track down the paper I read a year ago regarding receptor attachment camouflage I also ran across this possibility posted by our good friend Dr. Been -

https://m.facebook.com/watch/?v=2340073789601633&_rdr

https://investorshangout.com/post/view?id=5614503

If an increase in leronlimab to the brain is wanted there are several ways to disguise it to get through - fusion proteins, avidin-biotin and trojan horse liposomes.