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Posted On: 08/06/2020 5:05:24 PM
Post# of 145247
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Re: BBCOldCodger #47589
If the p-value at n=170 isn't good enough to get an interim halt for efficacy, it very likely won't be at n=195 either. We don't want to change the total number of patients required (390), only the interim analysis point.
The difference is only striking above 30% placebo mortality, but the difference is not so big that it would yield a result above 0.0294 which is one boundary used for interim analyses to allow for a halt, if I see correctly.
That is if my calculations are correct; and of course depends on the test they use..
The difference is only striking above 30% placebo mortality, but the difference is not so big that it would yield a result above 0.0294 which is one boundary used for interim analyses to allow for a halt, if I see correctly.
That is if my calculations are correct; and of course depends on the test they use..
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