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Posted On: 03/21/2020 7:23:57 PM
Post# of 72440
That may be correct. Other factors besides plasma half life can influence a drugs biologic effect. These include tissue distribution,binding to cellular receptive proteins and intracellular biologic effects. The latter 2 could change the pharmacodynamics from human cancer cells to viruses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990149/
https://www.ncbi.nlm.nih.gov/pubmed/28838028
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990149/
https://www.ncbi.nlm.nih.gov/pubmed/28838028
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