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Posted On: 12/10/2019 9:40:36 AM
Post# of 154183
Quote:
Proinflamatory cytokines secreted by innate immune cells, such as TNF-α, IL-1β, and IL-6 break down the BBB by reducing the expression of tight junction proteins (occludin, claudin-5 and ZO-1) and adherens junction proteins (VE-Cadherin) [5].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626569/
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