Random thought of the day, back in 2006, the half-life was listed longer. Then MT later miscalculated the half-life to 3.4 days, I posted the chart here from the paper showing that was wrong. Recently, NP thought 10 days.

Anyway there were dosing one weekly with 3.5 day half-life. With 10-14 day half-life, could they move that up to every 2 weeks to 4 weeks? Dr. Sacha I believe wants to use the 2 week dosing, but they might be able to do even longer.


http://www.natap.org/2006/HIV/022406_02.htm

Quote:

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Serum concentrations of PRO 140 increased proportionally with dose and decreased with a serum half-life of approximately 2 weeks.

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Quote:

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PRO 140 may represent a new treatment paradigm for HIV patients, because it has the potential to address the limitations of currently available therapies, including the emergence of multi-drug-resistant virus, significant side effects, drug-drug or drug-food interactions, and often-complex daily treatment regimens. In a recently completed phase 1 study in healthy volunteers, PRO 140 exhibited dose-dependent binding to CCR5-expressing cells. A single 5 mg/kg dose of PRO 140 significantly coated - and thereby potentially protected from HIV infection - CCR5 cells for as long as 60 days. PRO 140 was generally well tolerated at all dose levels in this study.

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