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Posted On: 07/15/2019 6:02:30 PM
Post# of 154874
Leronlimab will block all cells expressing CCR5, mostly human T-cells , dendrtitic cells , macrophages , Langerhans cells...
With macrophages is producing also polarization ....
Leronlimab is working by ..:
-- Stopping metastasis , by blocking CCR5
-- preventing resistance of cancer cells , ( by preventing repairing of DNA of cancer cells.)
-- regulate body anti-tumor response,
activating macrophages is one of the way is happening ....
We see polarization of macrophages ...process by which macrophages adopt different functional program ,
Macrophages M0, M1 , M2
M0- uncommitted macrophages
M1- classically activated -producing pro-inflammatory process and irritation to immune response.
M2-alternatively activated - turning on constructive process , like wound healing , producing anti-inflammatory cytokines.
In this study even with patchy scan in liver metastasis , patchy means there are at least 10% CCR5 negative cancer cells , there was still improvement .
They see more necrosis in tumors , look that effect is not only by blocking CCR5 , but also by polarization of macrophages , which destroying tumor cells ...
With macrophages is producing also polarization ....
Leronlimab is working by ..:
-- Stopping metastasis , by blocking CCR5
-- preventing resistance of cancer cells , ( by preventing repairing of DNA of cancer cells.)
-- regulate body anti-tumor response,
activating macrophages is one of the way is happening ....
We see polarization of macrophages ...process by which macrophages adopt different functional program ,
Macrophages M0, M1 , M2
M0- uncommitted macrophages
M1- classically activated -producing pro-inflammatory process and irritation to immune response.
M2-alternatively activated - turning on constructive process , like wound healing , producing anti-inflammatory cytokines.
In this study even with patchy scan in liver metastasis , patchy means there are at least 10% CCR5 negative cancer cells , there was still improvement .
They see more necrosis in tumors , look that effect is not only by blocking CCR5 , but also by polarization of macrophages , which destroying tumor cells ...
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