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Posted On: 07/15/2019 4:56:16 PM
Post# of 154881
Leronlimab will block macrophages, T cells, dendritic cells and all other cells expressing CCR5.
The difference between leronlimab vs. maraviroc is that maraviroc is a allosteric inhibitor and leronlimab is an entry inhibitor. Leronlimab blocks specific areas of the receptors maraviroc takes more of a blanket approach by binding to other molecules and that combination blocks CCR5.
I would guess the main problem with maraviroc and the cause of it's side effects is that it binds to isoleucine which stimulates immune function and controls other important functions.
The difference between leronlimab vs. maraviroc is that maraviroc is a allosteric inhibitor and leronlimab is an entry inhibitor. Leronlimab blocks specific areas of the receptors maraviroc takes more of a blanket approach by binding to other molecules and that combination blocks CCR5.
I would guess the main problem with maraviroc and the cause of it's side effects is that it binds to isoleucine which stimulates immune function and controls other important functions.
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