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Posted On: 02/04/2019 10:23:14 AM
Post# of 149547
Yes, thank you, all R5-tropic HIV-1 HAART.
With mono, they are putting up good numbers at the 700mg does, probably at the end will be 85%+ success, where the fda stated waiting 70% I believe. If you use the induction for 6 weeks, then continuation, that percent of success goes to 95%+ I'm guessing.
So expanding combo to all R5-tropic HIV-1 HAART patients, I give 90%+ chance.
To expand to mono only, I'm at 50/50. The FDA might look and see these spikes in VL when patients get the flu, etc, and feel they should have another drug working in a different way helping suppress VL in these situations. Or maybe the FDA will see some other issue, hard to say, which is why I am at 50/50. There is a reason no one has ever been approved for mono, very hard hill to climb.
With mono, they are putting up good numbers at the 700mg does, probably at the end will be 85%+ success, where the fda stated waiting 70% I believe. If you use the induction for 6 weeks, then continuation, that percent of success goes to 95%+ I'm guessing.
So expanding combo to all R5-tropic HIV-1 HAART patients, I give 90%+ chance.
To expand to mono only, I'm at 50/50. The FDA might look and see these spikes in VL when patients get the flu, etc, and feel they should have another drug working in a different way helping suppress VL in these situations. Or maybe the FDA will see some other issue, hard to say, which is why I am at 50/50. There is a reason no one has ever been approved for mono, very hard hill to climb.
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