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Posted On: 02/04/2019 1:54:50 AM
Post# of 154868
Quote:
With Mono , they have the numbers at 700mg, 92%, but full mono is a wild card in my opinion, since this would be the first ever FDA approved. Though expanding combo to all HAART seems very likely, at it has much less side-effects than the other approved ccr5 drug, Maraviroc, and more efficacy. My gut with this 50-50 on mono only approval, 90% chance for expanding to all HAART patients
PRO 140 can 'only' take over 70% R5-tropic of the ~72% HAART patients with Viral Load Suppression .. cough cough, but that is highly likely the game plan.
So yes, first we help the failed HAART patients via Combo and then take them to Mono as well ..
How sure are we regarding mono success? More than 90%, while still giving a 40% discount in our model for conservatism ..
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